Professor Matthew Cobb
BA, Habilitation, PhD
Michael Smith Building|Oxford Road|Manchester|M13 9PT
My laboratory studies how the sense of smell works. To do this we use a rather unusual animal - a maggot. You and I have about 4 million smell cells in our noses. A maggot has just 21, and by using genetics we can make a maggot with just a single smell cell in its nose. By studying the behaviour of these animals, and the electrical activity of their smell cells, we can understand how smells are processed in the nose and in the brain. Not only does a maggot have a brain, the bits of its brain that process smells are wired up just like ours. So by studying something as simple as a maggot we hope to understand how the sense of smell works in all animals, including humans.
- Hoare DJ, Humble J, Jin D, Gilding N, Petersen R, Cobb M, McCrohan C. (2011). Modeling peripheral olfactory coding in Drosophila larvae. PLoS ONE, 6(8), e22996. eScholarID:136784 | DOI:10.1371/journal.pone.0022996
- Claude Everaerts, Jean-Pierre Farine, Matthew Cobb, Jean-François Ferveur. (2010). Drosophila Cuticular Hydrocarbons Revisited: Mating Status Alters Cuticular Profiles. PLoS ONE, 5(3), e9607. eScholarID:110560 | DOI:10.1371/journal.pone.0009607
- Hoare DJ, McCrohan CR, Cobb M. (2008). Precise and fuzzy coding by olfactory sensory neurons. Journal of Neuroscience, 28(39), 9710-9722. eScholarID:1c7892 | DOI:10.1523/JNEUROSCI.1955-08.2008
- Patamarerk Engsontia, Alan P. Sanderson, Matthew Cobb, Kimberly K.O. Walden, Hugh M. Robertson and Stephen Brown. (2008). The red flour beetle's large nose: An expanded odorant receptor gene family in Tribolium castaneum. Insect Biochemistry and Molecular Biology, 38(4), 387-397. eScholarID:1c7347 | DOI:10.1016/j.ibmb.2007.10.005