Dr Rebecca Dearman
Michael Smith Building|Oxford Road|Manchester|M13 9PT
My research interests are at the interface between immunology (how our body protects us from infection), allergy (when our immune system is overprotective and causes harm) and toxicology (adverse health effects caused by foreign materials). Allergy is an important disease affecting up to 1 in 10 individuals, and is increasing. Allergy is also the most frequent form of adverse health effect (toxicology) impacting on the immune system.
Small reactive chemicals can cause allergic reactions in skin or lung and some proteins can cause asthma or food allergy. The research goals are to understand why only some chemicals and proteins cause allergy, what drives the different types of allergic responses and the cells and molecules involved, including whether preferences for the type of allergic responses can be imprinted on the immune system. One example is whether the pattern of sugar molecules on proteins plays a key role in promoting an allergic response.
This research should lead to the development of new and improved methods for the identification and characterisation of allergens, and also provide information about which cells and molecules are important, providing opportunities for new treatments of immune and inflammatory diseases.
- Almond, R., Flanagan, B., Antonopoulos, A., Haslam, S., Dell, A., Kimber, I. & Dearman, R (2013). Differential immunogenicity and allergenicity of native and recombinant human lactoferrins: Role of glycosylation. Eur J Immunol, 43(1), 170-181. eScholarID:177569 | PMID:23012214 | DOI:10.1002/eji.201142345
- Almond, R., Flanagan, B., Kimber, I. & Dearman, R (2012). Influence of protein expression system on elicitation of IgE antibody responses: experience with lactoferrin. Toxicology, 301(1-3), 50-7. eScholarID:177568 | PMID:22813905 | DOI:10.1016/j.tox.2012.06.018
- Lalko, J., Kimber, I., Gerberick, G., Foertsch, L., Api, A. & Dearman, R (2012). The direct Peptide reactivity assay: selectivity of chemical respiratory allergens. Toxicol Sci, 129(2), 421-31. eScholarID:177573 | PMID:22713598 | DOI:10.1093/toxsci/kfs205
- Dearman, R. & Kimber, I (2009). Animal models of protein allergenicity: potential benefits, pitfalls and challenges. Clin Exp Allergy, 39(4), 458-68. eScholarID:105737 | PMID:19178540 | DOI:10.1111/j.1365-2222.2008.03194.x