Dr Sheena Cruickshank
Immunology is the science of the immune system, the body’s defence against infection. From birth to death, we are bombarded with potential infectious threats that are immune system must recognise and respond to by killing or containing the threat. Yet, the immune system can be harmful too to us too when it isn’t properly controlled as is seen in allergies or autoimmune diseases like rheumatoid arthritis and Inflammatory Bowel Disease. Our research focuses on how our immune responses get started. Events that happen early in an immune response determine whether someone will be able to get rid of an infection or not or whether they get a chronic long-lasting infection or even an autoimmune disease like Inflammatory Bowel Disease. We look at how immune cells and bugs talk to each other and how this communication shapes the immune response in infection, inflammation (e.g. inflammatory bowel disease) and delayed wound-healing.
- Oscar FloÂ´ rez-Vargas, Michael Bramhall, Harry Noyes, Sheena Cruickshank, Robert Stevens, Andy Brass. (2014). The Quality of Methods Reporting in Parasitology Experiments. PLoS One, 9(7)(7), 101131. eScholarID:230736 | DOI:doi:10.1371/journal.pone.0101131
- Campbell L, Saville C, Kitagawa Y, Murray PJ, Cruickshank SM†, M Hardman. (2013). Dermal arginase 1 impairs cutaneous healing with an altered inflammatory response. Journal of Investigative Dermatology, 164, eScholarID:189954
- Campbell, L., Williams, H., Crompton, R., Cruickshank, S. & Hardman, M (2012). Nod2 deficiency impairs inflammatory and epithelial aspects of the cutaneous wound healing response. J Pathol, eScholarID:170053 | PMID:22951952 | DOI:10.1002/path.4095
- Cruickshank SM, Deschoolmeester ML, Svensson M, Howell G, Bazakou A, Logunova L, Little MC, English N, Mack M, Grencis RK, Else KJ, Carding SR. (2009). Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection. Journal of immunology (Baltimore, Md. : 1950), 182(5), 3055-62. eScholarID:1c8388 | PMID:19234202 | DOI:10.4049/jimmunol.0802749