Dr Sheena Cruickshank
AV Hill Building|Oxford Road|Manchester|M13 9PT
Immunology is the science of the immune system, the body’s defence against infection. From birth to death, we are bombarded with potential infectious threats that are immune system must recognise and respond to by killing or containing the threat. Yet, the immune system can be harmful too to us too when it isn’t properly controlled as is seen in allergies or autoimmune diseases like rheumatoid arthritis and Inflammatory Bowel Disease. Our research focuses on how our immune responses get started. Events that happen early in an immune response determine whether someone will be able to get rid of an infection or not or whether they get a chronic long-lasting infection or even an autoimmune disease like Inflammatory Bowel Disease. We look at how immune cells and bugs talk to each other and how this communication shapes the immune response in infection, inflammation (e.g. inflammatory bowel disease) and delayed wound-healing.
- Dalton JE, Cruickshank SM, Egan CE, Mears R, Newton DJ, Andrew EM, Lawrence B, Howell G, Else KJ, Gubbels MJ, Striepen B, Smith JE, White SJ, Carding SR. (2006). Intraepithelial gammadelta(+) Lymphocytes Maintain the Integrity of Intestinal Epithelial Tight Junctions in Response to Infection. Gastroenterology, 131(3), 818-29. eScholarID:1c5314 | PMID:16952551 | DOI:10.1053/j.gastro.2006.06.003
- Forester ND, Cruickshank SM, Scott DJA, Carding SR. (2006). Increased Natural Killer Cell Activity in Abdominal Aortic Aneurysms. Brit J Surgery, 93, 46-54.. eScholarID:1c7194 | DOI:10.1002/bjs.5215
- Cruickshank SM, Wakenshaw L, Cardone J, Howdle PD,Murray PJ and Carding SR. (2008). Evidence for the involvement of CARD15/NOD2 in regulating colonic epithelial cell growth and survival. World Journal of Gastroeneterology, 14(38), 5834-5841. eScholarID:1c7287 | DOI:10.3748/wjg.14.5834
- Cruickshank SM, Deschoolmeester ML, Svensson M, Howell G, Bazakou A, Logunova L, Little MC, English N, Mack M, Grencis RK, Else KJ, Carding SR. (2009). Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection. Journal of immunology (Baltimore, Md. : 1950), 182(5), 3055-62. eScholarID:1c8388 | PMID:19234202 | DOI:10.4049/jimmunol.0802749
PhD projects available
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