Professor Martin Humphries
BSc, PhD, FMedSci
Michael Smith Building|Oxford Road|Manchester|M13 9PT
Sticking, or adhesion, of cells, either to other cells or to the tissue proteins that surround them in the body, is a vital part of multicellular life. Adhesion is needed for holding the body together and for keeping millions of cells in the right place. During the course of many diseases, cells use adhesion to move abnormally throughout the body. Consequently, drugs that control adhesion might be useful for treating cardiovascular diseases, asthma, cancer, bacterial infections and ulcers. The work conducted in this lab uses new techniques to study the ways in which adhesion controls cell behaviour. If successful, the work will help us to understand more about how the molecules involved in adhesion work. It might also suggest ways to design drugs to control adhesion.
- Morgan, M., Hamidi, H., Bass, M., Warwood, S., Ballestrem, C. & Humphries, M (2013). Syndecan-4 phosphorylation is a control point for integrin recycling. Dev Cell, 24(5), 472-85. eScholarID:213700 | PMID:23453597 | DOI:10.1016/j.devcel.2013.01.027
- Bass, M., Williamson, R., Nunan, R., Humphries, J., Byron, A., Morgan, M., Martin, P. & Humphries, M (2011). A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis. Developmental cell, 21(4), 681. eScholarID:134911 | PMID:21982645 | DOI:10.1016/j.devcel.2011.08.007
- Humphries, J., Byron, A., Bass, M., Craig, S., Pinney, J., Knight, D. & Humphries, M (2009). Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal, 2(87), ra51. eScholarID:2579 | PMID:19738201 | DOI:10.1126/scisignal.2000396
- Kong, F., García, A., Mould, A., Humphries, M. & Zhu, C (2009). Demonstration of catch bonds between an integrin and its ligand. Journal of cell biology, 185(7), 1275. eScholarID:2580 | PMID:19564406 | DOI:10.1083/jcb.200810002
PhD projects available
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