Dr Jean-Marc Schwartz
Michael Smith Building|Oxford Road|Manchester|M13 9PT
Systems Biology is a new field of biology that seeks to develop detailed computational models of living cells and organisms. Biological cells are highly complex by nature, therefore we need to analyse large amounts of experimental data and know about all the molecular transformations and interactions going on in cells to be able to reconstruct accurate quantitative models. Such models have the potential to save considerable time and money to biological and pharmaceutical research by enabling us to simulate large numbers of experiments 'in silico' and make predictions about the effects of nutrition, drugs and environmental changes on living organisms.
- Chen D, Saha V, Liu JZ, Schwartz JM, Krstic-Demonacos M. (2013). Erg and AP-1 as determinants of glucocorticoid response in acute lymphoblastic leukemia. Oncogene, 32(25), 3039-3048. eScholarID:170810 | DOI:10.1038/onc.2012.321
- Tseng YY, Hunt SM, Heintzen C, Crosthwaite SK, Schwartz JM. (2012). Comprehensive Modelling of the Neurospora Circadian Clock and Its Temperature Compensation. PLoS Computational Biology, 8(3), e1002437. eScholarID:159207 | DOI:10.1371/journal.pcbi.1002437
- Adiamah DA, Handl J, Schwartz JM. (2010). Streamlining the construction of large-scale dynamic models using generic kinetic equations. Bioinformatics, 26(10), 1324-1331. eScholarID:79777 | DOI:10.1093/bioinformatics/btq136
- Kritz MV, Trindade dos Santos M, Urrutia S, Schwartz JM. (2010). Organising metabolic networks: cycles in flux distributions. Journal of Theoretical Biology, 265(3), 250-260. eScholarID:80081 | DOI:10.1016/j.jtbi.2010.04.026
PhD projects available
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