Dr Kimberly Mace
Michael Smith Building|Oxford Road|Manchester|M13 9PT
Non-healing diabetic wounds are the leading cause of non-traumatic amputations in the developed world. Current treatments for chronic wounds are often not effective due to a poor understanding at the molecular and cellular level of why these wounds develop. Recently, it has become clear that dysregulation of bone marrow-derived cells (BMDCs) is one of the causative factors. This has opened up new avenues of research, and applications of novel strategies to control BMDC behaviour show great promise for future therapies. Our research team investigates how manipulation of BMDCs can reverse impaired wound healing. In particular, we have developed a novel method of cellular reprogramming that we have successfully applied to dysfunctional BMDCs in diabetic mice. This technology is safe, as it does not require genetic manipulation, and is highly effective. Our immediate goal is to optimise this reprogramming technique to correct the dysfunctional behaviour of diabetic murine BMDCs during wound healing in vivo. The long-term goal of this research is to carry this technology forward for use on diabetic patients with chronic wounds. By reprogramming a patients’ own BMDCs, we can develop a safe and effective cell therapy to aid healing.
- Mace KA, Yu DH, Paydar KZ, Boudreau NB, Young DM. (2007). Sustained expression of Hif-1a in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair and Regeneration, 15(5), 636-645. eScholarID:1c6838 | DOI:10.1111/j.1524-475X.2007.00278.x
- Mace KA, Restivo TE, Rinn JL, Paquet AC, Chang HY, Young DM, Boudreau NJ. (2009). HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells. Stem Cells, 27(7), 1654-1665. eScholarID:76863 | DOI:10.1002/stem.90
- Kimberly A. Mace and Nancy Boudreau. (2010). Plasmid-Based Gene Transfer of Homeobox Genes and Improved Wound Healing. In Chandan K. Sen (Ed.), Advances in Wound Care. USA: Mary Ann Liebert, Inc.. eScholarID:76866
- Mahdipour E, Charnock JC, Mace KA. (2011). Hoxa3 promotes the differentiation of hematopoietic progenitor cells into proangiogenic Gr-1+CD11b+ myeloid cells. Blood, 117(3), 815-826. eScholarID:119488 | DOI:10.1182/blood-2009-12-259549
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