Our research is currently funded with research grants totaling ~£10 million from - UK government: BBSRC; European Commission: EU FP7
Our research is currently funded with research grants totaling ~£10 million from - Charities: The Wellcome Trust; The Leverhulme Trust.
Our research is currently funded with research grants totaling ~£10 million from - Companies: Life Technologies Corporation; Lonza Biologics PLC.
Our research funding supports over 60 full time researchers including post doctoral workers and PhD students
Highlight Publication:
Jennings MD, Pavitt GD. (2010). eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation.
Nature, 465(7296), 378-381.
Grant Success:
Leverhulme Trust project Grant for ~£146K awarded to The University of Manchester for research carried out in Dr Susan Crosthwaite's and Dr Sam Griffiths-Jones' laboratories.
‘New insights into the function of non-protein-coding antisense RNA’.
Highlight Publication:
Castelli LM, Lui J, Campbell SG, Rowe W, Zeef LA, Holmes LE, Hoyle NP, Bone J, Selley JN, Sims PF, Ashe MP. (2011). Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated.
Molecular Biology of the Cell, 22(18), 3379-3393.
Grant Success
Chris Grant and Simon Hubbard have been awarded £2.4M by BBSRC to study
‘Global Quantification of the Yeast Proteome’
Highlight Publication:
Sellick CA, Croxford AS, Maqsood AR, Stephens G, Westerhoff HV, Goodacre R, Dickson AJ. (2011). Metabolite profiling of recombinant CHO cells: Designing tailored feeding regimes that enhance recombinant antibody production.
Biotechnol Bioeng,, 108(12), 3025-31.
Highlight Publication:
Lee HC, Li L, Gu W, Xue Z, Crosthwaite SK, Pertsemlidis A, Lewis ZA, Freitag M, Selker EU, Mello CC, Liu Y. (2010). Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi.
Molecular Cell, 38(6), 803-814.
Highlight Publication:
Sideri, T.C., Stojanovski, K., Tuite, M.F. & Grant, C.M (2010). Ribosome-associated peroxiredoxins suppress oxidative stress-induced de novo formation of the [PSI+] prion in yeast.
Proceedings of the National Academy of Sciences of the United States of America, 107(14), 6394-9.
Grant Success
Anil Day has been awarded ~£359K by BBSRC to study:
‘Plastid genome maintenance and transplastomic technologies in crops’
Grant Success
Alan Dickson and colleagues have been awarded ~£819K by BBSRC to study:
‘Predictable Protein Production’
Highlight Publication:
Sellick CA, Jowitt TA, Reece RJ (2009).
The Journal of Biological Chemistry, 284: 229-36.
Highlight Publication:
Hunt SM, Thompson S, Elvin M, Heintzen C. (2010). VIVID interacts with the WHITE COLLAR complex and FREQUENCY-interacting RNA helicase to alter light and clock responses in Neurospora.
Proc Natl Acad Sci U S A, 107(38), 16709-16714.
Grant Success
Graham Pavitt, Mark Ashe, Chris Grant, Simon Hubbard and Paul Sims have been awarded £2.3M by BBSRC to study:
‘How RNA Interacting Proteins Modulate the Translatability of mRNAs’
Highlight Publication:
Gisby M, Mellors P, Madesis P, Ellin M, Laverty H, O’Kane S, Ferguson MWJ, Day A. (2011) A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule.
Plant Biotechnology Journal, 9(5), 618-628.
Highlight Publication:
Walid Omara, B. Rash, A. Hayes, M. Wickham, S. Oliver, L. Stateva. (2010) Conditional cell-wall mutants of Saccharomyces cerevisiae as delivery vehicles for therapeutic agents in vivo to the GI tract.
Journal of Biotechnology, 147, 136-143.
Highlight Publication:
McGrail JC, Krause A, O'Keefe RT. (2009) The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing.
Nucleic Acids Research, 37, 4205-4217.