University home |
The University of Manchester logo
The University of Manchester logo
 

Immunology and Molecular Microbiology

Overview

The Immunology and Molecular Microbiology group integrate fundamental research on the biology of infectious microbes from bacteria through to multicellular parasites with studies on the induction, regulation and resolution of innate and adaptive immunity.

Research group leader: Professor Richard Grencis

Principal investigators

Members

  • Jen Cavet - Metal homeostasis in enteric bacteria and adaptation to metal stress
  • Shiu-Wan Chan - Cellular adaptation to hepatitis C virus
  • Kevin Couper - Immunity to malaria infection
  • Sheena Cruickshank - Dissecting cellular and pathogen interactions
  • Rebecca Dearman - The role of immune cells, particularly dendritic cells, in shaping the polarisation of allergic responses to chemicals and proteins
  • Jeremy Derrick - The structural biology of cell surface proteins in bacterial pathogens
  • Curtis Dobson - Novel host / pathogen interactions in the CNS: a basis for developing new anti-infective drugs?
  • Kath Else - Immune responses to gastrointestinal helminth infections
  • Richard Grencis - Immunoregulation following parasite infection
  • Finbarr Hayes - Understanding plasmid segregation and maintenance
  • Nicola High - The role of bacterial glycoconjugates in infectious disease and their interactions with the host immune system
  • Ian Kimber - The cellular and molecular characteristics of adverse health effects resulting from the interaction of xenobiotics with the immune system
  • Dennis Linton - Understanding the mechanisms and function of glycosylation in bacterial pathogens of man
  • Douglas Millar - Regulation of autoimmune responses by antigen presenting cells
  • Werner Muller - Cellular Cytokine Networks
  • Pawel Paszek - Multi-scale inflammatory signaling in time and space
  • Ian Roberts - The expression of capsular polysaccharides in bacterial pathogens and the physiological adaptation of bacterial pathogens to growth inside the host
  • Geoff Robson - Fungal pathogens of man and the role of fungi in biodeterioration in the environment
  • Mark Travis - Regulation of immune responses in autoimmunity and infection

Affiliates

  • David Brough - Understanding how injury stimulates inflammatory responses and how this inflammation contributes to disease
  • Matthew Hardman - Identifying the basic cellular and molecular mechanisms that lead to delayed wound healing
  • Alan Roseman - Cryo-electron microscopy
  • Dave Thornton - Molecular assembly and biology of mucus
Environmental SEM of living Pleurotus mycelium.

Environmental SEM of living Pleurotus mycelium.

The adherence of Helicobacter pylori to gastric epithelial cells.

The adherence of Helicobacter pylori to gastric epithelial cells.

Structure of the bifunctional dihydroneopterin aldolase.

Structure of the bifunctional dihydroneopterin aldolase.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

Macrophages.

Macrophages.

CD8 T-cells infiltrating pancreatic islets.

CD8 T-cells infiltrating pancreatic islets.

Insulin expression in pancreatic islet.

Insulin expression in pancreatic islet.

Culture dishes.

Culture dishes.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

Immunology and molecular microbiology image.

T. muris larvae and eggs.

T. muris larvae and eggs.

 

Our research

Molecular pathogenicity uses an integrated multi-disciplinary approach to understand the mechanisms by which pathogens are able to colonise, survive in and damage the host."

Molecular ecology involves studies of how microbes survive, grow and behave in the natural environment, their interactions with other organisms, and their ability to colonise and recycle both natural and man-made materials.

Immunology applies an integrated in vitro and in vivo approach to defining the mechanisms underlying disease processes, from induction through to resolution. Our overall aim is to understand the molecular, cellular and in vivo basis of immune responses to antigenic challenge.

 

More about Immunology

Visit the Manchester Immunology Group website for futher details of our work in Immunology.