Professor Ian Roberts
Michael Smith Building|Oxford Road|Manchester|M13 9PT
Interactions between pathogens and the host.
Research in my laboratory is focused on the interactions between bacteria and their human hosts. Pathogenic bacteria are responsible for a number of life threatening infections of man and have devised strategies to overcome the host host’s defences. Specifically, they produce “virulence factors” that manipulate and re-program the ability of the host to combat the infection and it is the success or failure of this battle that will decide the outcome of the infection. In addition to looking at specific interactions between the pathogen and the host we are also looking at global changes that occur in the host as a consequence of the infection. In particular, we are looking at the microflora of the human gut and studying how infection both acute and chronic may alter the human gut flora and what are the consequences to the health of the host. We are studying two bacterial pathogens Escherichia coli responsible for urinary tract infections and Listeria monocytogenes a serious food borne pathogen. In addition, we are studying the effects of infection by the parasitic worm Trichuris muris on the host gut microflora.
- Corbett, D., Wang, J., Schuler, S., Lopez-Castejon, G., Glenn, S., Brough, D., Andrew, P., Cavet, J. & Roberts, I (2012). Two zinc uptake systems contribute to the full virulence of Listeria monocytogenes during growth in vitro and in vivo. Infect Immun, 80(1), 14-21. eScholarID:175749 | PMID:22025520 | DOI:10.1128/IAI.05904-11
- Corbett, Schuler, Glenn, Andrew, Cavet, Roberts. (2011). The combined actions of the copper-responsive repressor CsoR and copper-metallochaperone CopZ modulate CopA-mediated copper efflux in the intracellular pathogen Listeria monocytogenes. Molecular Microbiology, 81(2), 457-472. eScholarID:130241 | DOI:10.1111/j.1365-2958.2011.07705.x
- Hayes, K., Bancroft, A., Goldrick, M., Portsmouth, C., Roberts, I. & Grencis, R (2010). Exploitation of the Intestinal Microflora by the Parasitic Nematode Trichuris muris. Science, 328(5984), 1391-1394. eScholarID:90770 | PMID:20538949 | DOI:10.1126/science.1187703
- Hafez, M., Hayes, K., Goldrick, M., Grencis, R. & Roberts, I (2010). The K5 Capsule of Escherichia coli Strain Nissle 1917 Is Important in Stimulating Expression of Toll-Like Receptor 5, CD14, MyD88, and TRIF Together with the Induction of Interleukin-8 Expression via the Mitogen-Activated Protein Kinase Pathway in Epithelial Cells. Infection and immunity, 78(5), 2153. eScholarID:90773 | PMID:20145095 | DOI:10.1128/IAI.01406-09
PhD projects available
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