Publications
The following publications give a flavour of the work being carried out by the Immunology and Molecular Microbiology researchers in the Faculty.
d’Elia R., Behnke JM, Bradley JE., and Else KJ. (2009) Regulatory T cells: a role in intestinal helminth survival and the control of host pathology. Journal of Immunology 182, 2340-2348
Full text doi:10.4049/jimmunol.0802767 | PubMed entry PMID: 19201888
Cruickshank, S. M., M. L. DeSchoolmeester, Svensson, Howell G, Bazakou A, Logunova L. Little MC, English N, Mack M, Grencis RK, Else KJ, Carding SR. (2009). "Rapid Dendritic Cell Mobilisation to the Large Intestinal Epithelium is Associated with Resistance to Trichuris muris Infection." Journal of Immunology 182: 3055-3062
Full text doi:10.4049/jimmunol.0802749 | PubMed entry PMID:19234202
Ashcroft AJ, Cruickshank S, Croucher PI, Perry MJ, Rollinson SJ, Lippitt JM, Child JA, Dunstan C, Morgan GJ, Carding SR. Colonic Dendritic Cells, colitis and T cell-mediated bone destruction are modulated by recombinant Osteoprotegerin. Immunity. 2003 19: 849-861.
Full text doi:10.1016/S1074-7613(03)00326-1 | PubMed entry PMID:14670302
Cliffe LJ, Humphreys NE, Lane TE, Potten CS, Booth C and Grencis RK (2005) Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science. 308, 1463-1465.
Full text doi:10.1126/science.1108661 | PubMed entry PMID:15933199
Humphreys NE, Xu D, Hepworth MR, Liew FY, Grencis RK (2008) IL-33, a potent inducer of adaptive immunity to intestinal nematodes. Journal of Immunology. 180, 2443-2449.
PubMed entry PMID:18250453
Fasnacht N, Greweling MC, Bollati-Fogolín M, Schippers A, Müller W. (2009) T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection. Eur J Immunol.
Full text doi:10.1002/eji.200838710 | PubMed entry PMID:19593768
Schippers A, Leuker C, Pabst O, Kochut A, Prochnow B, Gruber AD, Leung E, Krissansen GW, Wagner N, Müller W. (2009) Mucosal Addressin Cell-Adhesion Molecule-1 Controls Plasma-Cell Migration and Function in the Small Intestine of Mice. Gastroenterology.
Full text doi:10.1053/j.gastro.2009.05.039 | PubMed entry PMID:19450594
Rickard AH, Gilbert P, High NJ, Kolenbrander PE, Handley PS (2003) Bacterial coaggregation: an integral process in the development of multi-species biofilms. Trends in microbiology 11(2): 94-100.
Full text doi:10.1016/S0966-842X(02)00034-3 | PubMed entry PMID:12598132
Rickard AH, Leach SA, Hall LS, Buswell CM, High NJ, Handley PS (2002) Phylogenetic relationships and coaggregation ability of freshwater biofilm bacteria. Applied and environmental microbiology 68(7): 3644-50.
Full text doi:10.1128/AEM.68.7.3644-3650.2002 | PubMed entry PMID:12089055
Harrison OB, Evans NJ, Blair JM, Grimes HS, Clow KJ, Tinsley CR, Kriz P, Ure R, Gray SJ, Derrick JP, Maiden MCJ, Feavers IM (2009) Epidemiological evidence for the role of the haemoglobin receptor, HmbR, in meningococcal virulence. Journal of Infectious Disease. In press.
PubMed entry PMID: 19476432
Cleverley RM, Saleem M, Kean J, Ford RC, Derrick JP, Prince SM, (2008) Selection of membrane protein targets for crystallization using PFO-PAGE electrophoresis. Molecular membrane biology 25(8): 625-30.
Full text doi:10.1080/09687680802448530 | PubMed entry PMID:18982523
Linton D, Dorrell N, Hitchen PG, Amber S, Karlyshev AV, Morris HR, Dell A, Valvano MA, Aebi M, Wren BW (2005) Functional analysis of the Campylobacter jejuni N-linked protein glycosylation pathway. Molecular microbiology 55(6): 1695-1703.
Full text doi:10.1111/j.1365-2958.2005.04519.x | PubMed entry PMID:15752194
Dorrell N, Karlyshev AV, Linton D, Wren BW, Barrow PA, Jones MA, Marston KL, Maskell DJ, Woodall CA (2004) Adaptation of Campylobacter jejuni NCTC11168 to high-level colonization of the avian gastrointestinal tract. Infection and immunity 72(7): 3769-76.
Full text doi:10.1128/IAI.72.7.3769-3776.2004 | PubMed entry PMID:15213117
Wortman J S, Mabey Gilsenan J, Joardar V, et al. (2009) The 2008 update of the Aspergillus nidulans genome annotation: A community effort. Fungal Genetics and Biology 46(S1): 2-13.
PubMed entry PMID: 19146970
Robson GD (2008) Phospholipases of Aspergillus fumigatus. ASM Press, Washington Aspergillus fumigatus and Aspergillosis: 12.
Banner MA, Cunniffe JG, Macintosh RL, Foster TJ, Rohde H, Mack D, Hoyes E, Derrick J, Upton M, Handley PS, (2007) Localized tufts of fibrils on Staphylococcus epidermidis NCTC 11047 are comprised of the accumulation-associated protein. Journal of bacteriology 189(7): 2793-804.
Full text doi:10.1128/JB.00952-06 | PubMed entry PMID:17277069
Corrigan RM, Rigby D, Handley PS, Foster TJ (2007) The role of Staphylococcus aureus surface protein SasG in adherence and biofilm formation. Microbiology 153: 2435-2446.
Full text doi:10.1016/j.fgb.2008.12.003 | PubMed entry PMID: 17660408
Derome A, Hoischen C, Bussiek M, Grady R, Adamczyk M, Kedzierska B, Diekmann S, Barillà D, Hayes F (2008) Centromere anatomy in the multidrug resistant pathogen Enterococcus faecium. Proc. Natl. Acad. Sci. USA 105: 2151-2156.
Full text doi:10.1073/pnas.0704681105
A Kulinska, M Czeredys, F Hayes, G Jagura-Burdzy (2008) Genomic and functional characterization of the modular broad-host-range RA3 plasmid, the archetype of the IncU group. Appl. Environ. Microbiol. 74: 4119-4132.
Full text doi:10.1128/AEM.00229-08
Peter Simmonds, Shiu-Wan Chan, Peng-Lee Yap (2007) Hepatitis C virus testing [granted patent with royalty income]. US 07179470.
MacCallum PR, Jack SC, Egan PA, McDermott BT, Elliott RM, Chan SW (2006) Cap-dependent and hepatitis C virus internal ribosome entry site-mediated translation are modulated by phosphorylation of eIF2alpha under oxidative stress. The Journal of General Virology. 87(Pt 11): 3251-62.
Full text doi:10.1099/vir.0.82051-0 | PubMed entry PMID:17030858
Beresford NJ, Mulhearn D, Szczepankiewicz B, Liu G, Johnson ME, Fordham-Skelton A, Abad-Zapatero C, Cavet JS, Tabernero L, (2009) Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages. The Journal of antimicrobial chemotherapy.
Full text doi:10.1093/jac/dkp031 | PubMed entry PMID:19240079
Taylor CM, Osman D, Cavet JS, (2009) Differential expression from two iron-responsive promoters in Salmonella enterica serovar Typhimurium reveals the presence of iron in macrophage-phagosomes. Microbial pathogenesis 46(2): 114-8.
Full text doi:10.1016/j.micpath.2008.11.001 | PubMed entry PMID:19049822
Yavuz E, Drouillard S, Roberts IS, Samain E, Priem B. (2008) Glucuronylation in Escherichia coli for the bacterial synthesis of the carbohydrate moiety of nonsulfated HNK-1. Glycobiology 18(2): 152-157.
Full text doi:10.1093/glycob/cwm134 | PubMed entry PMID: 18077549
Corbett D, Bennett HJ, Askar H, Green J, Roberts IS, (2007) SlyA and H-NS regulate transcription of the Escherichia coli K5 capsule gene cluster and expression of slyA in Escherichia coli is temperature dependent, positively auto-regulated and independent of H-NS. Journal of Biological Chemistry 282(46): 33326-33335.
Full text doi:10.1074/jbc.M703465200 | PubMed entry PMID:17827501
Dearman RJ, Cumberbatch M, Portsmouth C, Maxwell G, Basketter DA, Kimber I, (2008) Synergistic effects of chemical insult and toll-like receptor ligands on dendritic cell activation. Toxicology in vitro : an international journal published in association with BIBRA 22(8): 1927-34.
Full text doi:10.1016/j.tiv.2008.09.012 | PubMed entry PMID:18848616
Dearman RJ, Betts CJ, Caddick HT, Flanagan BF, Kimber I, (2008) Cytokine profiling of chemical allergens in mice: measurement of message versus protein. Toxicology 252(1-3): 17-25.
Full text doi:10.1016/j.tox.2008.07.055 | PubMed entry PMID:18708116
Sanchez-Soriano N, Travis M, Dajas-Bailador F, Gonçalves-Pimentel C, Whitmarsh AJ, Prokop A. (2009) Mouse ACF7 and Drosophila Short stop modulate filopodia formation and microtubule organisation during neuronal growth. Journal of Cell Science 122(14): 2534-42.
Full text doi:10.1242/jcs.046268 | PubMed entry PMID: 19571116
Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D, (2007) Loss of integrin alpha(v)beta(8) on dendritic cells causes autoimmunity and colitis in mice. Nature 449(7160): 361-5.
Full text doi:10.1038/nature06110 | PubMed entry PMID:17694047
Millar, Douglas G., Ohashi, Pamela S. (2007) Hsp70 family members, danger signals and autoimmunity. Springer Netherlands Heat Shock Proteins: Potent Mediators of Inflammation and Immuni: 189-211.
Full text doi:10.1007/978-1-4020-5585-0_13
Suzuki N, Suzuki S, Millar DG, Unno M, Hara H, Calzascia T, Yamasaki S, Yokosuka T, Chen NJ, Elford AR, Suzuki J, Takeuchi A, Mirtsos C, Bouchard D, Ohashi PS, Yeh WC, Saito T (2006) A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science 311(5769): 1927-32.
Full text doi:10.1126/science.1124256 | PubMed entry PMID:16574867
Pritchard DI, Todd I, Brown A, Bycroft BW, Chhabra SR, Williams P, Wood P. (2005) Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosasignal molecule, N-(3-oxododecanoyl)-L-homoserine lactone. Acta Diabetol 42: 119-222.
Full text doi:10.1007/s00592-005-0190-2
Lees J, Boam D, Proungvitaya T & Wood PJ (2004) Site specific regulation of tissue dendritic cell function by granulocyte/macrophage colonystimulating- factor. Immunology 113(4): 482-90.
Full text doi:10.1111/j.1365-2567.2004.01981.x