Physiological Systems & Disease
Our central team of molecular physiologists and pharmacologists explore the diverse roles of channels and transporters in neurons, muscle cells, epithelial cells and stem cells. We collaborate extensively with structural biologists and clinicians across the University, and with the pharmaceutical industry.
Research group leader: Prof Mark Dunne
- Pathophysiology of Hypertension
- Ion transport at the blood-cerebrospinal fluid barrier
- The general mechanisms that give rise to specific spatio-temporal patterns of intracellular Ca2+ signals in non-excit
- Fluid and electrolyte transport in epithelia
- Human Embryonic Stem Cells and Diabetes Mellitus
- Pancreatic endocrine cells and stem cell biology
- The regulation of vascular smooth muscle membrane potential and tone by the endothelial cells
- Calcium signalling, divalent cation transport and stimulus-response coupling in mammalian cells
- Molecular and Cellular Physiology of Voltage-gated Calcium Channels
- Ion channels regulating vascular tone in the pulmonary circulation
- Inositol lipid function and regulation
- Targeting of Ion Channels in the Central Nervous System
- Cardiac Physiology in Ectotherms
- Sensing and transport of essential nutrients
- Membrane transport in secretory epithelia
- The MAP Kinase Signalling Pathways in the Heart
- Extracellular Calcium Homeostasis
- Modulation of ion channels and gap junctions in the vasculature
- Growth and Growth factors
- Membrane protein biosynthesis at the endoplasmic reticulum
- Membrane Protein Structural Biology
- Mechanisms of protein quality control and their role in disease
A two photon image of airways and alveoli in an intact lung.
Environmental SEM of living Pleurotus mycelium.
Section through diabetic rat bladder showing expression of TREK-1 potassium channels in the urothelium (red)
A voltage-sensitive dye (yellow) outlines the membranes of smooth muscle cells in a living arteriole. Nucear stain blue.
False colour fura-2 ratio image showing calcium oscillations in HEK cells transfected with CaR.
Extracellular signals modulate cellular activity via complex, interconnecting pathways involving receptor proteins, membrane lipids, intracellular messengers and protein kinase cascades.
Ion channels have pivotal roles in neuronal activity, cardiovascular function and epithelial transport. Many are implicated in the aetiology of major diseases and are therefore important therapeutic targets.
Homeostasis, whether at the cellular or whole-organism level, depends upon the accurate sensing of important ions and molecules in order to direct appropriate feedback responses.
Membrane Protein Targeting:
The movement of channels and transporters between the ER, Golgi complex and cell surface has to be precisely regulated to ensure that membrane proteins are expressed in the correct numbers at the correct locations.
Numerous carriers and pumps are involved in the transport of ions and other solutes across the plasma membrane. Many have critical roles in the regulation of the intracellular environment, others in secretion and absorption by epithelia.
We welcome post-doctoral research fellows in fields complementary to our
research profiles and we would be pleased to consider a request to host your
fellowship. To this end, we are happy to provide advice, guidance and help with
If you wish to apply for a postdoctoral fellowship in any of the research areas
covered by Physiological Systems & Disease, please do not hesitate to
contact us. If appropriate, we are happy to organise a
visit for you to see our facilities and talk to specific group members. In
addition, we are happy to provide advice and guidance with application.